Epilepsy as Central Nervous System Involvement in Patient with ANCA-Associated Vasculitis: A Case Report

Main Article Content

Martínez Camacho Roberto de Jesús
Héctor Murillo Reyna
Lilia Itzel Martínez Camacho
María Fernanda Ruíz Gómez
Santiago Sandoval Correa
Hayil Linaldi Sierra
Francisco Alejandro González Orozco
Eduardo Nieves Paredes
Marcos Vela Rivera
Consuelo Alejandra Aguirre Gonzalez

Abstract

Central nervous system (CNS) involvement by antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare presentation. The affected nerve structure determines the symptoms of AAV. Presentation as seizures can make early diagnosis difficult by necessitating the ruling out of other etiologies, which increases mortality in these patients. Serological and imaging studies facilitate the identification of AAV and initiation of timely treatment focused on remission of the autoimmune pathology. We present the case of a young female patient who, after diagnosis with AAV by renal biopsy, presented with several epileptic seizures. With angioresonance, we evidenced vascular involvement and began remission treatment with an adequate resolution of the seizures.

Article Details

How to Cite
de Jesús, . M. C. R. . ., Murillo Reyna, H., Martínez Camacho, L. I., Ruíz Gómez, M. F. ., Sandoval Correa, S., Linaldi Sierra, H., González Orozco, F. A. ., Nieves Paredes , E., Vela Rivera, M., & Aguirre Gonzalez, C. A. (2024). Epilepsy as Central Nervous System Involvement in Patient with ANCA-Associated Vasculitis: A Case Report. International Journal of Medical Science and Clinical Research Studies, 4(01), 18–21. https://doi.org/10.47191/ijmscrs/v4-i01-04
Section
Articles

References

I. Paroli M, Gioia C, Accapezzato D. New Insights into Pathogenesis and Treatment of ANCA-Associated Vasculitis: Autoantibodies and Beyond. Antibodies (Basel). 2023 Mar 21

II. Fragoulis GE, Lionaki S, Venetsanopoulou A, Vlachoyiannopoulos PG, Moutsopoulos HM, Tzioufas AG. Central nervous system involvement in patients with granulomatosis with polyangiitis: a single-center retrospective study. Clin Rheumatol. 2018 Mar;37(3):737-747. doi: 10.1007/s10067-017-3835-y. Epub 2017 Sep 15.

III. Zheng Y, Zhang Y, Cai M, Lai N, Chen Z, Ding M. Central Nervous System Involvement in ANCA-Associated Vasculitis: What Neurologists Need to Know. Front Neurol. 2019 Jan 10;9:1166. doi: 10.3389/fneur.2018.01166.

IV. Graf J. Central Nervous System Disease in Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. Rheum Dis Clin North Am. 2017 Nov;43(4):573-578. doi: 10.1016/j.rdc.2017.06.006.

V. Wirrell E. Evaluation of First Seizure and Newly Diagnosed Epilepsy. Continuum (Minneap Minn). 2022 Apr 1;28(2):230-260. doi: 10.1212/CON.0000000000001074.

VI. Migdady I, Rosenthal ES, Cock HR. Management of status epilepticus: a narrative review. Anaesthesia. 2022 Jan;77 Suppl 1:78-91. doi: 10.1111/anae.15606.

VII. Yokoseki A, Saji E, Arakawa M, Kosaka T, Hokari M, Toyoshima Y, et al. Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody. Brain (2014) 137(Pt 2):520–36. doi: 10.1093/brain/awt314

VIII. Ferlazzo E, Gambardella A, Bellavia M, Gasparini S, Mumoli L, Labate A, Cianci V, Russo C, Aguglia U. Positivity to p-ANCA in patients with status epilepticus. BMC Neurol. 2014 Jul 17;14:148. doi: 10.1186/1471-2377-14-148.

IX. Sherri A, Mortada MM, Makowska J, Lewandowska-Polak A. Primary angiitis of the CNS and ANCA-associated vasculitis: from pathology to treatment. Rheumatol Int. 2023 Sep 30. doi: 10.1007/s00296-023-05461-9.

X. Sánchez-Román E, Monternach-Aguilar F, Reyes-Vaca JG, Rodríguez Leyva I (2021) Challenging presentation of primary vasculitis of the central nervous system. Cereb Circ Cogn Behav. https:// doi.org/10.1016/j.cccb.2021.100027

Most read articles by the same author(s)